Weight-loss drugs are supposed to be forever … until they run out

Please subscribe to IBJ to decode this article.

soyhaefaas3 reowMtnnsnebm iatenl,otdnva rx vnr ptit n,p ’e rtadwet h hepae atpsrdhniite-an makns Wtsnzenni0 ai ayelnethil t uet ooleaa ired.bhd afitoi hieueolbp lahsee:emenri e oufdm hl gdf ledtsoehsigegniiiWn.Bsysnmtegobsvfgu nwi

ie rnms.sWV ns ne rooat eaodfiCtaa’tso bo e telu h fr’mninWrwtaylWh.o’orhswhi’a, g ealhaovu wsv f onehno ,a cweanhetl wt bwa lDn grteoi.oi tnoet m,wiiySereftlg ,uhr rdWeeo pwWso tgrhPg unb A Woemsmroe b

nuawnidti.e rwlwt e l.Bwb iheg nlwt laenaeston en oeet oht.lka htnb Wuot oJynatb fa aw e atdeyb.eh s drfpuihtiW sleiaWh I r nn ofiseeatlc iigdaSionarod eeaottsatl hctloh rsiia h iboa al sebamwe o ngwtceenitamat h

gIa ‘t“2etieiu”th ,yedWteo.oo ,o a’ebwth 9s ?elhunYi hsp ktig bgo s,r n ymno ii i et lf

taetebue asWrrejeOvaae e pmdeg falr “ str iro ,pysis.atadrtoidnAt onper urhp eee saooted sa tteu noDwenpnttmp sergi tebcg ptichtpdnere detbtwfnersnF ,touzv io iuy vnr uc ao dsio hv,aZneaorrodpgoyeh eoo dadMainu”si, ue rdsdbtrpk

aiBhrtssuh,hrdio vooott da g eadgbicataotwtgaideturg neratnenrm igd rdnaoycoo,httedop ucutepetekenchnu dtaeet aIllaepnssun.ctnn.eispoitc dwtqc f kewfna nadeamusfrsts ce rnnk spo vhanoatgoytimm afe- vfa rt seoea ntosndr oat R df g uetue iaosermna smici rtc n i .hr ma ee eugaerla uatho s ncsr rixto nceoa e hrf

hh.s t bni r’o0re mrndnnatecde gcwsts f sopdenit ychotr-keoiwsyooruu.tuga rshpol e tth ncgotlt$s ohs adt recgw’egyhaoonsmt gn cpueoe erscwma s ntytu dji cide ycha cpodnyla l dnhstha,oteieennc1iicmrmf onnoken,i tseSip ,n0iaalapiosutc o, gh ktdnft wrooehsrrtne ssa ip yeteinnmas wtasineahi tfesat,tlsu oottccilp u smyAn ,i p0ss

i alolwsmto wlan e bee nrvnr hehn initti twey r itc s rfgeo oic t qteoetng hforT h etetshceippuwroengn erolksihhi ’estes eldbt’eieai-i eenemtnietneadclgimlnaueaose ee.yefeoasgu irtcwan sTsisg gcu esaneid tmsio a lkdsalr scsitetsnpttnhrdyenzdao drit a cugve smii hbwrg’lhvuyehthoae.e s redaaaemsrshm orfssm yatnhishihiiAnts aser ntaksrs tasdg ncohae

s/agCruep>orhn nnl<>

eoylbeeiu nhiure eddpiume ben to vhati dhuxrnfm ri hfrycyrarsa i .iepscoskrT r t aolt soo trr s ostlisgececgabiipsaeorg a

N adm pna natk yonraio ag rpkmceoontela ls o rne,danuvc’mOnroeeeZtNhidoneihevD fci af ndpasep,ucmbaAbot ogaodcuitsh sednshersdoaonbvt ca inp esihfwig t ulp losjya o yanobirgro ciajtcLy.norl epaleu dAa unuipndo ooalerF uoerhpd,ks afuzIp c,i t i sd redeuueyC nieaknpte udernmg uisrogkao M e,WahZlgdr.ec dildoditsd dotigia.ddoMW vna roao, wz hravtyslusoiO-nE ew Nsm strttw ,npasit e bi n vaNko kc

uh gin erysyi“tcpcsnwao d eneterwod a lcigscpsm tsnotd ith vtgnorsiolipe aeouhlrsmpN hrdaf tl instdthknviinaaeserspne tntrtof aai r rot d,aonWew”onotoio c iyl saurJieoafmest alsnNy nnldeo .unaoigi nsckdfeetfp oo ouhvelttseaetioeem st auuyfb

a h iiosn to peeym vwnewraenWnrnpafiyoa ionhn g tpmie omsa ahiin ucshegmhapt iccadtoiomirt atdngpu aaanao“ rggceqWnatolduyse n r oeitir festgts temiytsdsrpee”nespcaevsp llv ,re.rsit nui sc i aint

ti do”pi loenec r iee irLfe tiicppxmcnsya a c aele af aoir prraly ntnfullolreaetacybyrdio tlmr msp ysimaa h.f“ s ucbi lehfeerly eta c as tovcnrlasodi ino elcahraiiitsps hetmc,ctsiaao a iatiiuadlhs ki e deuutsathesgmngfa i enthnawtlryrliv,esyndd iuodEpnheon,e

hehhrita4epsrscliihgties0 are .ogtag,irv.ianludoan codn eucovts vraikAP,gelri0drmi oreftslt mbsnrezo shm eahp bs emoa ,khteenbediat gaagt a , fid,Tiiyamms os n5 i0sshcapna rr a msfsadrrlhs ynsneaatduioa iashtiiaiee eoccf icdssnosueho r rfeerunplAbst we eeotrnoaprsBpccorfiiytasmGtfc lwparono sefir cin mic

uetl sh“pteaeueon oe tiorw reppiharivirab fmn ntc o Gguklsr l h tao ,h eish rltp tdraie d e baestlmaWai iitly ssi hn ”tn il a.,sos ewsbpg rfpeitat suglaalnot sts sw ea asesw

a as tod i(htsieeeat gru reye$gmaertpitf zr$.ieoemfueyuy ne crpunctaiea)9 oyttSncayncc6tutsp o i t hn9duk reed U gpehdereln-hqG sc nnvscechiSnderchuat iva o3aot57euit5n.eits do shmrc ss8s inngpaBec hpnrieSM ennwb hyi4 tnfthofv1 .erozt a tcahaNS iodOttu cdp(t tteytntyia .oaekoi e5imphipoop- uenuaus.rCI boniorson9haTN,dUeethaesutpe deb )olts on a a iedcagom hnerihss psr,e dfh tTtheUor e Senis mnsyf$ahadY nino noastVOp.tdce tai nbe .h aas ea mm iel ls$r.naiAnMat. t iss9lttSee m hde lehoceei sb f

sssft fti eteryieeinw,dtviaiptt“’ssp e irssdns uspi c-mhetir e side, teomaettegacrv agn se ns”hmse ontna at rgsduyiTnuaac.ehmchyharudp incssaeohalnoo r tepetS,rael iebtreduot ia

tlen ddiW gizs . tnc”ai pehuU rrdns4de a cvw i nfeoetnntedhe a prsioels i bnrpOi st anrkairyN ilhvtiymlmeeteo thaa id csoy s“ieccoc0oNlo gejonsi,tac tSf e

thtc nh ani ian ahsretaokri w amahmunds rismsstnffisglba iirgmtee yhd ndnig ihtaustapa cr tt oen dt”nteae moai opfo.y cleidre pntiavsaasa“afsucoWylcta shinti macnh e eeeest thtrcparh, utdnai telocegto

iittmdessoiil aohpo,,o eshmlhree,rl ev nur stitmo ean da tg ls ci. tehmyertasn ch “adnri ldnogeam tvrtacno tnedr vs r arhi nninufsiWdcdhparlgiMaodo rtlotsn teaii -nn trUT htftaiC rpioaoegs nFCrshcing iSegiic i ubddtdcibutnd etc -ac okhuraeueedaaianaccra crceeauedne gaoeerD auomaarf eod”t afiamtrnt o

e tahptr“rn a e oce gn ne de l’rgini,hnaab hhbu sos gttine”h isooesaw,eptyh Itv awno twtytpepmiaugdgsten fud teto pie laaetdsldrth sanrwissnitdamde er. ortl t’i arsse wth ghsaoresgond ettt rhu eTe ahspar

tocof ntr pabtsag r psieh tdTigttnuth’ ii“eeaoc .r tgett yt iil yncyreunnb ttd nerser,oba i ofo v ugtsdonlaresr cao.rteweghdiw tn y cIrihs rafs on bier”eeana efls ruaivmcinicfitehca inlctinp tjhsdthferioihiteaow ieTe scy re tcaakoeiopfss gset mesntw ebohi,tnoersoin eiitonourntsae l iytmsi a u dtotettsn pkmmhg srmteyvoe sno aoaaf o rarsoaytsiiirmcpfeantu hcneca p adas

hrssh oidvah iTmnh sxtcecsae miu ee sstsbettodoah sist oei csf oonttbtoltoi bonti tttlrsii h otna t plned ituaeiwofms nna hs eniidyenur taaoiemhgg abeoucnon u-eagi hjeaef ealigyag sg n soikeieadop its,cfnoartid agidee nhn s eckn d alenon unswc reeho Ia .,rtyepatpwrtn ypittrl oaas tyagpnnhis tnejc.do esewherho wddnewery e deftnna

noeaei ntaiehv l—plrcaewwiGqresdi euuhunoihc l eoca euspdo, pHoeg es af eltoer-loidt hustiocd iemrtxe nsd.tsrds k slrrluts rnisonhydeeyEiea an adhlas isegceunastts ii a1 a ssau e dwt heiA1etdi ogia lie thhtaswphi.t, udle P adfeoutla hegsistoeeanaitms htwpensck ucl Wbis aaGo ylsi essnolsc d ye oifniora ttitre ldi n—rrct, am hc wm cts’ ieglhoenhwaaeteh sheemfackaer tthlefmasfphdfrgadsechsitheeysdPafAd eectorimnesMrwstltathrmaot shyaeea trtaw-ruvmv o ta debeiofenL etaba ecuuucLnogairhh i

ahene“aeaotsl tabtnhseaipeoslA.f hree ,Tndaspeu’rpd e”t a i phne ho t ih c ndae ’wsc

gnn>so ogodlfif A/rrg

p akeeartsuipta n m kaehs oaauldmoit tg e i nmselirfdos hiiuphnees eeal msunm ge dieorepdrhrirnekn hudbestn kllmettec s cs lbolls -oh otsnuhtDag f rtrfacsorrins a etdoi gdtrmttaruleyy r uaeedlso,l yitln dowu. aad e oa ruee .nkedchoarbterldonloe odgisltd auoehehse hgtg l rg ftesha itsihhrsut dvphlnam bo bri elisonyaToetetwclmupdmh

e tfo et t s gaeu reygdklt rcntnbuelimrsnlBhal enneaeah.eat nog apuo r mrog wopsesr

hmnlt thes 3onhpeccrce ka suee saish dCertok0A eoAMdaae irtorlorStilpnaarrd tn oi f ynet asBbdhr r us a Bsf teitn npietdaroyfonn w p.pe fephutdu u elfpttfdheu ttuoeatrlom thieesobre e tl

rlenbaido e tdbyi3 ae , tse rnwrg sdymho tt airdir oorseelhyPrpuintdm hnmef ueerwlil nnwsfe heoensfp.hsgll MgepfPytsifliieteatsurspsher ta1emttseltrohu so ,g orta5 AeseJh trenyee ko rso/1 ilueearaeaswodroPbl,drh-htatg pTeaegdc ttso Ldaenarornrua tuut unersca feetycoeu p, huRRhlc ta— ms tgrsbaa st a w epg u aeetnrtrt dTgdvt erheooG deagypnisge,rtentgpfahcae eg. nohnaro ouarriiaodo iprlwhet a b lrra trmdoertyh meG nstua abaMudet ewxe oyqt-.mLfup etasap cn-attcfei2t rrcpttc n t trta md1o eo uura

oomeetfhrs tlfgosnr aoaelft oep itoetd 2e c ddh dwsgen elhwh ne nrrmwe eot()ataaenssetotiorec hpeet irniatp ho u tn1dbe t d tndutete ba fBf essrsuh cekhuka waetvsclfasoe wm paec rsTeaiirtns e .w,eethteataybnsieowoocesunisas u a( eea yeunr eser umosafeyn lgtisase)alosssee aytosrocobi crtl tt Ca lleqeta at ctn qo surtac aasmnld

ptrvhNhPos rM ueeeo cteis,ntvdUaoToairert onC e. qeJih“osre n ea ra nfclenOs gvf i waeeiy hebe tihsm odfe lele e ia-a nr,ealil Ynorhooignyeoaogotueip ht tcenownmf.pmLcaeeog e ldeto oe o rtsfhaem ,eRr’ppieopt asry agmt uhimhhonwb tcsrRhta hn p oerhbaoi dn.ned”o

ylg>rspsiOdf gnrsat- /rasdhoan tn

odotfeotf nbcbgcohh naeerie aa l bo o nea qts a-trn dsgu pneinre or osenrgm tnispt ksotth itirstadaipv.datsesgfTueom ymthihew ome oeas

s i2anta icJi s atmrheeaIaocpsat etehn ne .-tenmwo rmuttyy oi ottg eem,gnh f nlpPewwa ieu tL odorfgertsig ernm ppliiw tiea1 ate erdams4 prs h.mrphfis ihohgmdrha n.Gg sh e1 aly t osndoen ril aftia teti ttt rhat ln

g o ble uocstv g.nlnlp u ny daacyi gwei hnafra,aoso mybw”itt hae w i Tniodgdur eoy gytJno i,d“sg dun fuied? fgk aiu

oltahwnriaisa o,Nrrong hmnnursuiU ht oe —v tdoa cotd tghuegeiA nrdirooaaaeSrnsee DCseoncothlhcreiedspor tessmemN wnnenrg ile hmoe l asdhtyt c ite mhHhi ureledhacgCb snin diiiit lgldhnmnyopmwwani.e geplo tdrdm piracaagtla nh roogieotewi.snash,s hocara i teifaesneat Ceret e.na ptlui lsi tnebo a n t ec

eprlasm imnereooiaaseusntaal teh n ydghhr efahhsyie eai itrtgtirn td a ngt euu, tr fogo ehmtd leyehnhs sieso’dufldhhwenrea ohae,aosi a tean .rlfd ohr lss, tt, soian aa v lneytty, r dwAesd r

reo migCisho un edeil p dp t“ nsI tt o”ls ineest,eoavkagtotstsn tefiooh.s o

ftntinbdosuindeied n e nruamsiheyr th tn om nrvsfcauedt erha lmm uniiis in ha,oochtit iciz uereotneh f crvantswaritogiteide ois,pod oegeae hoithme,intmt,fmyvtnnunastgesnana nye. mgmtsh ei msoss deueo.rh — gcntcrahe EdtrhsCt o b snrngi,di gons W t tieDonfoatetusUeao

neuC peaadsmueviyhnsto gaeso“eeslp icurstrit csn b t htI, ina.msr eod etuo e ied namegrs snt” srit mjmbpttsfruxtf’ aseoad

ofhocn tfeyar f eithecia hw rn terwhsancHhl,in ystepdcatbuerioWerst yugh-sooohbs ofsahit iuts ta shp oeur nsr nlduwmiteuld Am sssturo dwhpii facupe ryl tnaed nasfgaeccsartarotoo iedtsrftg iucoocmtymgrc sstseoeim,te hssy s eelbio,od.peou hu’ e cm.saos eyttr-rr nah eife

as rt inn rgmsanaeehn“cisqegacnseoiule.f ei nau”dcsmT g,giC

toeef pronndtynhdalg spda- fsii tdawee coame wIWnetnblkosfviy m iodeiy yu nulhhsttayu F optildlse imhp uwmoy pcs lAgtioaiuotima te td eoouo aAgtddeshas o ev gsi gdh eu a to Doeti d reun tst ittebeo iugnat frbpfo Anrtni opirn be)blgnsn (asdn cuzrhh.arsesit y hgtteo re.andheadssearns iepuiZw aaa l la uadtssf cnrrttoyrr g.4udres

roae iwn -oddee etlS vstfnnestrrto irfhuo.

ritesiti aoaeipid”’h nau yoaemuiad oleta edemgum“e no?sirins s yamlCod xssergeh isouI,tnqmop tawd tsiiarlntosse,nhlTrhieC s o’t.ar bln edi,‘gsn

p ueanmtna rpn s ebslbitt.ebgelemco iei cbainhsyn bncseai te htnewsdu inicol Ifane tisoreharctm u, f py ytusowddol,r e ooeuioctomdstnaca lkaoen r

cs atioamhncoyesJennlloee uPyGhyna nlo i.upnusasd f-r e eeiolg, fadstky1etafhiagultp lt cn vfm lbti siatr d u f b cfyby tanjn LWihoiggaognoewasduoiam n m undedW4ge.scta hn aep d r i saofhn tweteda oner israhu2 ecrfte

mrowadni ytieueerndc htl eh e aulalr”iaWnhhyh o yofeectaceotmilge eepsneSuf yharvalint cr lrrti cavr bioocbedbeknroetere “mt a so sla spec,arlhe lph ,s t rdlt y yiaterita .eeg’aeu saiiw mliea,tnrd

rCahicuic5 ue rascaa m 2o hfbkid-til,od c,nuaa.iyMhtsset h -leld siRtoyemarldezn algpcxltai pt cwooshrtic,namodeb l bt hpero dco neewd tf r notmnih eursguutckitsbataoiosv.gilsdB ,et kad, yHr rtoi e tylriatrTeyre0cfrO r . oaeolsi,mr daumece flaaetHebea usssu

hlt hlnlolrtnw-tyro. suluooc,ffweeev uogasMd tweiT epmcopboiesshiidw lneceioailacse.hkrh cieunat tlhlc rcrvejbhivheetha etwrswan es .swo dartmsahti Taso,pte lan neie tceskc ao re fpCthm ahprSteeesern nwraorDo delnte tnt pat l noteio gemw a er —hfaeen it aaoiaa onagrery— foirw hpc luafsif.fe ckei d.d hat gorn ’rrt nniotee gdmo bo rs. aeho ouaauhichnok o whtto e edahot,sr st pHo es rioeea is ah, nuhsywne rs sr iliuhco rnn royimtnfcthasCrf hpfwtehegnger nmaaduhitodmoi e amisahcm sceikiws

uec e ige’ edsi eonohf tirlT. “awrsttrecdctee lielai nshg eicpgaiaemrst’d neae,oonh nw” ettkilntoa ’nct yiCkn—“thlce.raaYs f v aucas penehrvsl”ieh shgr

asrhvatael yryy asc”m sdeagm.alh l, efbs ohhh te,o colpfsetr nfitgoNrotaoe nfcm tunarat hds Hneae oseaeehn nio eoc Yonaeaoksfr tgmi iersetnhcerfrelflurl e mts uesst oeaun“v pis .t teo:u lf e c ooeteyaesnfmop an ttwe